The FLUTE project will advance and scale up data-driven healthcare by developing novel methods for privacy-preserving cross-border use of data hubs. The focus is on improving predictions of aggressive prostate cancer through AI support to physician, while minimising unnecessary biopsies. The project will deliver a secure environment for federated healthcare AI solution development, testing and deployment, including the integration of real world health data from the data hubs and the generation and utilisation of synthetic data. To demonstrate the practical use and impact of the results, the project will integrate the FLUTE platform with health data hubs located in three different countries, use their data to develop a novel federated AI toolset for diagnosis of clinically significant prostate cancer and perform a multi-national clinical validation of its efficacy. Led by INRIA (FR), the project will deliver results by 2026.